Article

PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast Cancer

2025-10-19

Abstract excerpt

SWI/SNF chromatin remodelers utilize ATP to mobilize nucleosomes on DNA and are represented by three biochemically distinct subcomplexes, the more abundant cBAF and the less abundant PBAF and GBAF subcomplexes. Patient mutations and genetic studies have identified important roles for PBAF subunits in development and disease; however, relating PBAF-mediated phenotypes to biochemical function in chromatin regulation...

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Literature Corpus work: c07a51ad-7f41-50d1-a5ae-3cfd9375955a
DOI: 10.1101/2025.10.19.683137

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