Article

A <i>cis</i> -regulatory element regulates <i>ERAP2</i> expression through autoimmune disease risk SNPs

2023-03-03

Abstract excerpt

Single nucleotide polymorphisms (SNP) near the ERAP2 gene are associated with autoimmune conditions such as Crohn’s disease , and birdshot chorioretinopathy , as well as protection against lethal infections, including the Black Death . Due to high linkage disequilibrium (LD), a great number of trait-associated SNPs are correlated with ERAP2 expression, however their functional mechanisms remain unidentified....

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Literature Corpus work: 3885e0ab-c454-5191-988a-94ecb4adb7e9
DOI: 10.1101/2023.03.03.530973

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