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CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects <i>IRF8</i> expression through cooperative lncRNA and DNA methylation machinery

2021-06-12

Abstract excerpt

Dysregulated transcription factors represent a major class of drug targets that mediate the abnormal expression of many critical genes involved in SLE and other autoimmune diseases. Although strong evidence suggests that natural human genetic variation affects basal and inducible gene expression, it is still a considerable challenge to establish a biological link between GWAS-identified non-coding genetic risk var...

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Literature Corpus work
649232bd-9efd-50a3-b266-77ddc3e0783c
DOI
10.1101/2021.06.11.448156
Open publication

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CRISPRa screen on a genetic risk locus shared by multiple autoimmune diseases identifies a dysfunctional enhancer that affects <i>IRF8</i> expression through cooperative lncRNA and DNA methylation machineryDOI 10.1101/2021.06.11.448156
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