Article
Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs.
Molecular systems biology - 16 Oct 2014
Adoue Veronique, Schiavi Alicia, Light Nicholas, Almlöf Jonas Carlsson, Lundmark Per, Ge Bing, Kwan Tony, Caron Maxime, Rönnblom Lars, Wang Chuan, Chen Shu-Huang, Goodall Alison H, Cambien Francois, Deloukas Panos, Ouwehand Willem H, Syvänen Ann-Christine, Pastinen Tomi
Abstract excerpt
Most complex disease-associated genetic variants are located in non-coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis-regulatory impact (cis-rSNPs). We used AE mapping to identify cis-rSNPs regulating gene expression in 55 and 63 HapMap lymphoblastoid cell lines from a Caucasian and...
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