Article
Identification of intergenic trans-regulatory RNAs containing a disease-linked SNP sequence and targeting cell cycle progression/differentiation pathways in multiple common human disorders.
Cell cycle (Georgetown, Tex.) - 1 Dec 2009
Glinskii Anna B, Ma Jun, Ma Shuang, Grant Denise, Lim Chang-Uk, Sell Stewart, Glinsky Gennadi V
Abstract excerpt
Meta-analysis of genomic coordinates of SNP variations identified in genome-wide association studies (GWAS) of up to 712,253 samples (comprising 221,158 disease cases, 322,862 controls, and 168,233 case/control subjects of obesity GWAS) reveals that 39% of SNPs associated with 22 common human disorders are located within intergenic regions. Chromatin-state maps based on H3K4me3-H3K36me3 signatures show that many...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.