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Article

Protective genes and pathways in Alzheimer's disease: moving towards precision interventions.

Molecular neurodegeneration - 29 Apr 2021

Seto Mabel, Weiner Rebecca L, Dumitrescu Logan, Hohman Timothy J

Abstract excerpt

Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks. The etiology of Alzheimer's is complex, with numerous environmental and genetic factors contributing to the disease. Late-onset AD is highly heritable (60 to 80%), and over 40 risk loci for AD have been identified via large...

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PMID: 33926499
DOI: 10.1186/s13024-021-00452-5
PMCID: PMC8086309

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