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Candidate Molecular Subtypes of Cognitive Resilience in Alzheimer’s Disease: A Multi-Cohort Machine Learning and Neuroimaging Study

2024-08-26

Abstract excerpt

<h4>Background</h4> Cognitive resilience (CR) in Alzheimer’s disease (AD) refers to preserved cognitive function despite substantial AD pathology. Diverse biological processes have been implicated in CR, including synaptic maintenance, neuroimmune regulation, and metabolic homeostasis. However, how these mechanisms are organized into molecularly distinct CR subtypes and relate to clinical and neuroanatomical hete...

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Literature Corpus work
b8ffc933-730a-559d-8610-70b59be95781
DOI
10.1101/2024.08.25.609610
Open publication

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Candidate Molecular Subtypes of Cognitive Resilience in Alzheimer’s Disease: A Multi-Cohort Machine Learning and Neuroimaging StudyDOI 10.1101/2024.08.25.609610
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