Article

Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotency

2025-07-04

Abstract excerpt

The Y chromosome harbors few protein-coding genes, and their roles in early human development remain largely unclear. Here, we demonstrate that UTY, a Y-linked homolog of the histone demethylase UTX, plays a critical, demethylase-independent role in maintaining pluripotency in human embryonic stem cells (hESCs). Despite its low expression and weak enzymatic activity, UTY co-occupies active cis-regulatory elements...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 387ea1a7-1490-596e-9120-4fb9f784a463
DOI: 10.1101/2025.07.03.663017

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional redundancy between UTY and UTX in regulating the localization of transcription factors involved in pluripotencyDOI 10.1101/2025.07.03.663017Read

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.Semantic proximity Read

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.Semantic proximity Read

Regulatory effects of the Uty / Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cellsSemantic proximity Read

Upregulation of the lncRNA XACT sustains pluripotency, blocks lineage specification, and drives germ cell tumor-like transcriptional programs in human pluripotent stem cellsSemantic proximity Read

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.Semantic proximity Read

YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian EpiblastSemantic proximity Read

DUX is a non-essential synchronizer of zygotic genome activationSemantic proximity Read

Systematic identification of Y-chromosome gene functions in mouse spermatogenesisSemantic proximity Read

Activin/nodal signalling controls the epigenome and epitranscriptome of human pluripotent stem cellsSemantic proximity Read

Utx loss causes myeloid transformation.Semantic proximity Read

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and Is Essential for Teratoma Formation.Semantic proximity Read

The N-terminus of Stag1 is required to repress the 2C program by maintaining rRNA expression and nucleolar integritySemantic proximity Read