Article

DUX is a non-essential synchronizer of zygotic genome activation

2019-03-06

Abstract excerpt

Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA and blastocyst maturation. Here, we demonstrate that mice carrying homozygous Dux deletions display markedly reduced expression of DUX target genes and defects i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dda410c3-f073-50dd-9847-8ff25fba41c5
DOI: 10.1101/569434

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DUX is a non-essential synchronizer of zygotic genome activationDOI 10.1101/569434Read

DUX is a non-essential synchronizer of zygotic genome activation.Semantic proximity Read

Transcription activation of early human development suggests DUX4 as an embryonic regulatorSemantic proximity Read

DUX4 regulates oocyte to embryo transition in humanSemantic proximity Read

Transgenic mouse models for investigating human <i>DUX4</i> expression during development and its roles in FSHD pathophysiologySemantic proximity Read

Herpesviruses mimic zygotic genome activation to promote viral replicationSemantic proximity Read

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene inductionSemantic proximity Read

A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activationSemantic proximity Read

Modelling human zygotic genome activation in 8C-like cells <i>in vitro</i>Semantic proximity Read

Herpesviruses mimic zygotic genome activation to promote viral replicationSemantic proximity Read

Biphasic myopathic phenotype of mouse DUX, an ORF within conserved FSHD-related repeats.Semantic proximity Read

DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesisSemantic proximity Read

Herpesviral induction of germline transcription factor DUX4 is critical for viral gene expressionSemantic proximity Read