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Article

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.

PLoS genetics - 1 Sept 2012

Shpargel Karl B, Sengoku Toru, Yokoyama Shigeyuki, Magnuson Terry

Abstract excerpt

UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Uty. Homozygous Utx mutant female embryos are mid-gestational lethal with defects in neural tube, yolk sac, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23028370
DOI: 10.1371/journal.pgen.1002964
PMCID: PMC3459986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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