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Systematic identification of Y-chromosome gene functions in mouse spermatogenesis

23 Jan 2025

Abstract excerpt

The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In Eif2s3y , Uty , and Zfy2 deletants, spermatogenesis was impaired. We found that Uty regulates spermatogonial proliferation, revealed a role for Zfy2 in promoting meiotic sex chromosome pairing, and uncovered unexpected effects of Y...

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PMID: 39847625
DOI: 10.1126/science.ads6495

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