Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Utx loss causes myeloid transformation.

Leukemia - 1 Jun 2018

Zheng Liting, Xu Longyong, Xu Qing, Yu Lu, Zhao Danfeng, Chen Pu, Wang Wei, Wang Yiqin, Han Gang, Chen Charlie Degui

Abstract excerpt

Recurrent somatic loss-of-function mutations in histone demethylases are frequently detected in cancer. However, whether loss of a histone demethylase can cause cancer has not been determined. Here, we report that knockout of the histone demethylase Utx in mice causes a chronic myelomonocytic leukemia (CMML)-like disease with splenomegaly, monocytosis, and extramedullary hematopoiesis. Mutational analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Differentiation
Share to Cell Lineage
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hematopoietic Stem Cells

Share to Histone Demethylases

Share to Histones

Share to Leukemia, Myelomonocytic, Chronic

Share to Mice, Knockout

Source

Identifiers

PMID: 29479066
DOI: 10.1038/s41375-018-0011-6

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Utx loss causes myeloid transformation.PMID 29479066Read ↗

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.Semantic proximity Read ↗

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.Semantic proximity Read ↗

Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis.Semantic proximity Read ↗

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming.Semantic proximity Read ↗

UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.Semantic proximity Read ↗

DISORDERED HISTONE METHYLATION IN HEMATOLOGICAL MALIGNANCIES THE CASE OF UTX/KDM6A.Semantic proximity Read ↗

Epigenetic drug library screening identified an LSD1 inhibitor to target UTX-deficient cells for differentiation therapySemantic proximity Read ↗

Cancer-derived UTX TPR mutations G137V and D336G impair interaction with MLL3/4 complexes and affect UTX subcellular localization.Semantic proximity Read ↗

Identification of EXO1 as a potential biomarker associated with prognosis and tumor immune microenvironment for specific human cancers.Semantic proximity Read ↗

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemiaSemantic proximity Read ↗

A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.Semantic proximity Read ↗

An in vivo genetic reversion highlights the crucial role of Myb-Like, SWIRM, and MPN domains 1 (MYSM1) in human hematopoiesis and lymphocyte differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.