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Article

HIV Restriction by APOBEC3 in Humanized Mice

28 Mar 2013

Abstract excerpt

Innate immune restriction factors represent important specialized barriers to zoonotic transmission of viruses. Significant consideration has been given to their possible use for therapeutic benefit. The apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family of cytidine deaminases are potent immune defense molecules capable of efficiently restricting endogenous retroelements as well as a...

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PMID: 23555255
DOI: 10.1371/journal.ppat.1003242

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