Article
Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.
Retrovirology - 14 Aug 2008
Esnault Cécile, Priet Stéphane, Ribet David, Heidmann Odile, Heidmann Thierry
Abstract excerpt
BACKGROUND: APOBEC3 cytosine deaminases have been demonstrated to restrict infectivity of a series of retroviruses, with different efficiencies depending on the retrovirus. In addition, APOBEC3 proteins can severely restrict the intracellular transposition of a series of retroelements with a strictly intracellular life cycle, including the murine IAP and MusD LTR-retrotransposons. RESULTS: Here we show that the...
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