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Article

TET2-CHIP: From Mutation to Malady.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 May 2026

Jian Heng, Sun Mingyang, Xia Xinyi, Su Chengke, Su Kai, Xu Jiahao, Yuan Yuanfan, Li Chenxi, Yu Miao, Cheng Xiang

Abstract excerpt

Somatic mutations in hematopoietic cells can drive clonal expansion without overt malignancy, a condition defined as clonal hematopoiesis of intermediate potential (CHIP). Among CHIP driver genes, TET2 is notable for its high prevalence and strong association with cardiovascular disease (CVD) and chronic inflammation. TET2 encodes a methylcytosine dioxygenase essential for epigenetic regulation, and its loss...

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Identifiers

PMID: 42186714
DOI: 10.1096/fj.202600383R

Genes

TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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