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The multi-Siglec inhibitor AL009 reprograms suppressive macrophages and activates innate and adaptive tumor immunity

2023-08-05

Abstract excerpt

Sialic acid–binding immunoglobulin-type lectins (Siglecs) are cell surface receptors that regulate innate and adaptive immunity, with inhibitory Siglecs promoting immune tolerance. In the tumor microenvironment, overexpression of sialic acid glycans exploits inhibitory Siglec signaling, leading to a cancer-permissive phenotype. AL009 is an engineered Siglec-9-Fc fusion molecule that functions as a sialic acid trap...

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Literature Corpus work
c842cd7a-13e6-52da-be2e-442b8ad68078
DOI
10.1101/2023.08.02.551627
Open publication

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The multi-Siglec inhibitor AL009 reprograms suppressive macrophages and activates innate and adaptive tumor immunityDOI 10.1101/2023.08.02.551627
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