Article

CRISPR activation screens map the genomic landscape of cancer glycome remodeling

2025-05-27

Abstract excerpt

Many cancer types upregulate expression of sialic acid-containing glycans. These oligosaccharides subsequently engage inhibitory Siglec receptors on immune cells, allowing cancer cells to evade immune surveillance. The genetic mechanisms by which this glycome remodeling occurs remain poorly defined. Understanding the ways that cancer cells change their cell surface glycosylation is critical for identification of b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95b58fe1-b6bc-5e51-8d1f-fce99a9c6e3f
DOI: 10.1101/2025.05.26.656133

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CRISPR activation screens map the genomic landscape of cancer glycome remodelingDOI 10.1101/2025.05.26.656133Read

Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockadeSemantic proximity Read

Ex vivo and in vivo CRISPR/Cas9 screenings identify the roles of protein N-glycosylation in regulating T-cell activation and functionsSemantic proximity Read

Functional genomics identifies extension of complex N-glycans as a mechanism to evade lysis by natural killer cellsSemantic proximity Read

A Transient Expression System with Stably Integrated CRISPR-dCas9 Fusions for Regulation of Genes Involved in Immunoglobulin G GlycosylationSemantic proximity Read

GALE-dependent glycoproteome remodelling is a determinant of oncogenic RAS transformationSemantic proximity Read

The transcriptional landscape of glycosylation-related genes in cancerSemantic proximity Read

CRISPR screens establish regulatory maps of immunosuppressive surface molecules in cancerSemantic proximity Read

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumorsSemantic proximity Read

Key Cancer Glycosylation-related Genes Analysis: Regulatory, Therapeutic, and Prognostic InsightsSemantic proximity Read

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.Semantic proximity Read

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screensSemantic proximity Read

Metabolic precision labeling enables selective probing of O-linked <i>N</i> -acetylgalactosamine glycosylationSemantic proximity Read