Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma

Abstract excerpt

Glycosylation is the most complex post-translational modification of proteins. Altered glycans on the tumor- and host-cell surface and in the tumor microenvironment have been identified to mediate critical events in cancer pathogenesis and progression. Tumor-associated glycan changes comprise increased branching of N -glycans, higher density of O -glycans, generation of truncated versions of normal counterparts,...

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