Article

N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity

2023-01-23

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has had limited success in solid tumors, requiring novel enhancement strategies. Modifying the glycocalyx of CAR T cells is unexplored; we report on genome-editing of the MGAT5 gene to abolish human CAR T N-glycan poly-LacNAc modifications. This boosted tumor control in carcinoma and lymphoma models, for donors of whom the non-engineered CAR T cells largely failed in...

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Identifiers and source

Literature Corpus work: a145f4bc-4943-5297-9894-dd593a601fd2
DOI: 10.1101/2023.01.23.525164

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