Article

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

2025-03-17

Abstract excerpt

<h4>Background</h4> The immunosuppressive tumour microenvironment (TME) reduces immune response effectiveness in stromal-rich tumours, including CMS4 colorectal cancer (CRC). Mesenchymal stromal cells (MSCs), precursors to cancer-associated fibroblasts (CAFs), promote cancer progression by suppressing anti-tumour immune responses. Hypersialylation of glycans on tumours engages Siglec receptors on immune cells, dr...

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Literature Corpus work: 153de200-7c72-58c6-a117-a5567d1d91d9
DOI: 10.1101/2025.03.14.642985

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