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Unraveling the glyco-immunity nexus in pancreatic cancer

4 Aug 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease, and standard of care therapies have failed to yield significant clinical benefit, with invasive surgery being the only curative treatment for patients with early-stage disease. Tumor-associated glycans in pancreatic cancer have direct effects on the survival and propagation of the tumor proper and contribute to an immunosuppressed tumor...

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PMID: 40759948
DOI: 10.1186/s12943-025-02417-4

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