Article

LINE-1 expression in cancer correlates with DNA damage response, copy number variation, and cell cycle progression

2020-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Retrotransposons are genomic DNA sequences that are capable of copying themselves to new genomic locations via RNA intermediates; LINE-1 is the only retrotransposon that remains autonomous and active in the human genome. The mobility of LINE-1 is largely repressed in somatic tissues, but LINE-1 is active in many cancers. Recent studies using LINE-1 constructs indicate that host cells activate a...

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Literature Corpus work: 37fdb509-e244-58a0-87df-5d6522862ad2
DOI: 10.1101/2020.06.26.174052

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