Article
Evolutionary insights from profiling LINE-1 activity at allelic resolution in a single human genome.
The EMBO journal - 1 Jan 2024
Yang Lei, Metzger Genevieve A, Padilla Del Valle Ricky, Delgadillo Rubalcaba Diego, McLaughlin Richard N
Abstract excerpt
Transposable elements have created the majority of the sequence in many genomes. In mammals, LINE-1 retrotransposons have been expanding for more than 100 million years as distinct, consecutive lineages; however, the drivers of this recurrent lineage emergence and disappearance are unknown. Most human genome assemblies provide a record of this ancient evolution, but fail to resolve ongoing LINE-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.