Article

Evolutionary insights from profiling LINE-1 activity at allelic resolution in a single human genome

2022-11-17

Abstract excerpt

Transposable elements including LINE-1 (Long INterspersed Element-1) impact genome variation, function, regulation, and disease. LINE-1s seem to have expanded as distinct consecutive lineages, but the drivers of lineage emergence and disappearance are unknown. Reference genomes provide a snapshot of LINE-1 evolution; however, the ongoing retrotransposition of LINE-1s in humans is not evident in these mosaic assemb...

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Literature Corpus work: c55c52c7-fea1-59c5-967a-9e6fc597e91f
DOI: 10.1101/2022.11.17.516944

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