Article

Peripheral sTREM2-related inflammatory activity alterations in early stage Alzheimer’s disease

2021-08-12

Abstract excerpt

Alzheimer’s disease (AD) has been linked to multiple immune system genetic variants, implicating potential broad alterations in inflammatory profiles in the disease. Triggering receptor expressed on myeloid cells 2 (TREM2) genetic variants are risk factors for AD and other neurodegenerative diseases. A soluble TREM2 isoform (sTREM2) is elevated in cerebrospinal fluid in the early stages of AD suggesting it may be...

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Literature Corpus work: 37f8bc64-b3a2-57f9-9fbb-1f89542d78aa
DOI: 10.1101/2021.08.12.455916

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