Article

Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome

2019-09-19

Abstract excerpt

Individuals with Down syndrome (DS) develop Alzheimer’s disease (AD) - related neuropathology, characterized by amyloid plaques with amyloid β (Aβ) and neurofibrillary tangles with tau accumulation more frequently and at an earlier age than their neurotypical counterparts. Peripheral inflammation and the innate immune response are elevated in DS. Triggering receptor expressed in myeloid cells 2 (TREM2) genetic var...

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Literature Corpus work: 9fd3c327-538d-5bca-bbfe-8776ca2fbe03
DOI: 10.1101/776583

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