Article

MX2 viral substrate breadth and inhibitory activity are regulated by protein phosphorylation

2022-01-25

Abstract excerpt

Human immunodeficiency virus type-1 (HIV-1) infection is potently inhibited by human myxovirus resistance 2 (MX2/MxB), which binds to the viral capsid and blocks the nuclear import of viral DNA. We have recently shown that phosphorylation is a key regulator of MX2 antiviral activity, with phosphorylation of serine residues at positions 14, 17 and 18 repressing MX2 function. Here, we extend the study of MX2 post-tr...

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Literature Corpus work: 37e616f0-fa78-5cfe-8a36-b046497521bd
DOI: 10.1101/2022.01.24.477574

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