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Article

Phosphorylation of T425 and methylation of R426 synergistically regulate IBDV VP1 function and viral replication.

Veterinary microbiology - 1 Feb 2026

Liang Huiping, Gao Xiangxiang, Xiao Yan, Sun Rongzhao, Chen Biao, Zeng Qinghua, Chen Zheng, Wu Xiangdong, Wu Huansheng

Abstract excerpt

Post-translational modifications (PTMs) are essential regulators of viral protein function and replication efficiency. Infectious bursal disease virus (IBDV) polymerase VP1 has been reported to undergo multiple PTMs; however, the interplay among different modifications remains poorly understood. In this study, we identified a novel phosphorylation site at threonine 425 (T425) adjacent to the previously...

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Identifiers

PMID: 41506171
DOI: 10.1016/j.vetmic.2026.110871

Genes

PRMT5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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