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Article

Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication.

PLoS pathogens - 1 Jan 2013

Rahman Masmudur M, Liu Jia, Chan Winnie M, Rothenburg Stefan, McFadden Grant

Abstract excerpt

Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways. In order to investigate additional functions of M029, we have constructed a series of targeted M029-minus (vMyx-M029KO and vMyx-M029ID) and V5-tagged M029 MYXV. We found that M029 plays a pivotal role in determining the cellular tropism of MYXV in all...

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Identifiers

PMID: 23853588
DOI: 10.1371/journal.ppat.1003465
PMCID: PMC3701710

Genes

DHX9

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