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Article

The inactive X chromosome as a female protector in autism and beyond

2025-09-08

Abstract excerpt

<title>Abstract</title> <p>Why do human females require more autosomal genetic risk to manifest autism compared to males? Why is this also true of other male-biased, childhood-onset conditions with substantial autosomal heritability? Here we propose that the higher female liability threshold for these disorders arises due to gene expression from the human inactive X chromosome (Xi), which buffers the effects of d...

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Literature Corpus work
37e4e82a-ce32-5bb8-9bdf-474cd6ac1f19
DOI
10.21203/rs.3.rs-7539254/v1
Open publication

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The inactive X chromosome as a female protector in autism and beyondDOI 10.21203/rs.3.rs-7539254/v1
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