Article

Sex differences in the developing human cortex intersect with genetic risk of neurodevelopmental disorders

2025-09-05

Abstract excerpt

Autism is highly heritable and diagnosed more frequently in males than females. To identify neurodevelopmental processes that might present sex-biased vulnerability, we generated transcriptomic and epigenomic profiles of cell types present in the prenatally developing human cerebral cortex of 27 males and 21 females. By intersecting sex-biased molecular signatures and genes with de novo mutations in male and fema...

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Literature Corpus work: 658694db-6c8c-5924-9964-56f519c190ab
DOI: 10.1101/2025.09.04.674293

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