Article
Escape from X chromosome inactivation and female bias of autoimmune diseases.
Molecular medicine (Cambridge, Mass.) - 9 Dec 2020
Mousavi Mohammad Javad, Mahmoudi Mahdi, Ghotloo Somayeh
Abstract excerpt
Generally, autoimmune diseases are more prevalent in females than males. Various predisposing factors, including female sex hormones, X chromosome genes, and the microbiome have been implicated in the female bias of autoimmune diseases. During embryogenesis, one of the X chromosomes in the females is transcriptionally inactivated, in a process called X chromosome inactivation (XCI). This equalizes the impact of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.