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Article

Hypothesis: dysregulation of methylation of brain-expressed genes on the X chromosome and autism spectrum disorders.

American journal of medical genetics. Part A - 1 Sept 2008

Jones Julie R, Skinner Cindy, Friez Michael J, Schwartz Charles E, Stevenson Roger E

Abstract excerpt

The hypothesis is set forth that dysregulation of brain-expressed genes on the X chromosome constitutes the major predisposition to autism spectrum disorders (ASDs). This dysregulation, mediated by hypomethylation or hypermethylation of CpG sites within gene promoters, leads to overexpression or partial silencing of one or more brain-expressed genes, which in turn results in an unbalanced production of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18698615
DOI: 10.1002/ajmg.a.32396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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