Article

Brain X chromosome inactivation is not random and can protect from paternally inherited neurodevelopmental disease

2018-11-02

Abstract excerpt

Non-random (skewed) X chromosome inactivation (XCI) in the female brain can ameliorate X-linked phenotypes, though clinical studies typically consider 80-90% skewing favoring the healthy allele as necessary for this effect 1–10 . Here we quantify for the first time whole-brain XCI at single-cell resolution and discover a preferential inactivation of paternal to maternal X at ∼60:40 ratio, which surprisingly impac...

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Literature Corpus work: f599b6cb-bfbf-5871-bc4a-7fe7c1ba99df
DOI: 10.1101/458992

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