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Article

The inactive X chromosome as a female protector in autism and beyond.

Nature genetics - 1 Apr 2026

Talukdar Maya, Page David C

Abstract excerpt

Female individuals require greater autosomal genetic risk than male individuals to manifest autism, yet the biological basis of this 'female protective effect' (FPE) remains unknown. Based on insights into the human sex chromosomes, we propose that the FPE arises from higher expression of a subset of X-linked genes in females due to transcription from both the active (Xa) and inactive (Xi) X chromosomes. These...

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PMID: 41912931
DOI: 10.1038/s41588-026-02534-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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