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K2P18.1 translates T cell receptor signals into thymic regulatory T cell development

26 Oct 2021

Abstract excerpt

Abstract It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that drive the cell fate decisions towards conventional (Tconv) or regulatory T cells (Treg). Following TCR activation, intracellular calcium (Ca 2+ ) is the most important second messenger, for which the potassium channel K 2P 18.1 is a relevant...

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PMID: 34702947
DOI: 10.1038/s41422-021-00580-z

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