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Article

Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice.

ACS chemical neuroscience - 15 May 2024

Parvin Farjana, Haglund Samuel, Wegenast-Braun Bettina, Jucker Mathias, Saito Takashi, Saido Takaomi C, Nilsson K Peter R, Nilsson Per, Nyström Sofie, Hammarström Per

Abstract excerpt

Amyloid plaques composed of fibrils of misfolded Aβ peptides are pathological hallmarks of Alzheimer's disease (AD). Aβ fibrils are polymorphic in their tertiary and quaternary molecular structures. This structural polymorphism may carry different pathologic potencies and can putatively contribute to clinical phenotypes of AD. Therefore, mapping of structural polymorphism of Aβ fibrils and structural evolution...

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Identifiers

PMID: 38652895
DOI: 10.1021/acschemneuro.4c00104
PMCID: PMC11099915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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