Article

Divergent age-dependent conformational rearrangement within Aβ amyloid deposits in APP23, APPPS1, and App <sup>NL-F</sup> mice

2023-10-27

Abstract excerpt

Amyloid plaques composed of fibrils of misfolded Aβ peptides are pathological hallmarks of Alzheimer’s disease (AD). Aβ fibrils are polymorphic in their tertiary and quaternary molecular structures. This structural polymorphism may carry different pathologic potency and can putatively contribute to clinical phenotypes of AD. Therefore, mapping of structural polymorphism of Aβ fibrils is valuable to understand dise...

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Literature Corpus work: 1a991e04-86a1-54ce-9fd8-96eeffe63bdb
DOI: 10.1101/2023.10.24.563716

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