Article

Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery

2026-02-22

Abstract excerpt

<title>Abstract</title> Tauopathies are characterized by the accumulation of abnormally phosphorylated tau filaments, with disease-specific folds revealed by cryo-electron microscopy (cryo-EM). Here, we delivered a recombinant human tau carrying the P301L/S320F double mutation into <italic>App</italic> <italic>NL−G−F</italic> / <italic>MAPT</italic> double knock-in mice using a blood-brai...

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Literature Corpus work: 8ade632f-a8db-5864-8ce8-f679d056417a
DOI: 10.21203/rs.3.rs-8696738/v1

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