Article

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression

2017-07-19

Abstract excerpt

LINE-1 mobile genetic elements have shaped the mammalian genome during evolution. A minority of them have escaped fossilization which, when activated, can threaten genome integrity. We report that LINE-1 are expressed in substantia nigra ventral midbrain dopaminergic neurons, a class of neurons that degenerate in Parkinson disease. In Engrailed-1 heterozygotes, these neurons show a progressive degeneration that s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 37c073ed-235f-5101-b88e-cf28290378f3
DOI: 10.1101/164608

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repressionDOI 10.1101/164608Read

LINE-1 activation in the cerebellum drives ataxiaSemantic proximity Read

Nigral Transcriptomic Profiles in Engrailed-1 Hemizygous Mouse Models of Parkinson’s Disease Reveal Upregulation of Oxidative Phosphorylation-Related Genes Associated with Resistance to Dopaminergic NeurodegenerationSemantic proximity Read

Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons.Semantic proximity Read

Homeoprotein neuroprotection of embryonic neuronal cellsSemantic proximity Read

SIRT1 limits neuronal fate following DNA damageSemantic proximity Read

Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neuronsSemantic proximity Read

Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.Semantic proximity Read

Endonuclease VIII ‐like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's diseaseSemantic proximity Read

Interplay Between Retroviral Element De-repression and Wnt/β-Catenin Pathway in Cellular Models of Parkinson’s DiseaseSemantic proximity Read

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis.Semantic proximity Read

Perturbed DNA methylation by sustained overexpression of Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death in miceSemantic proximity Read

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.Semantic proximity Read