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Article

Engrailed genes are cell-autonomously required to prevent apoptosis in mesencephalic dopaminergic neurons.

Development (Cambridge, England) - 1 Jul 2004

Albéri Lavinia, Sgadò Paola, Simon Horst H

Abstract excerpt

The neuropathological hallmark of Parkinson's disease is the loss of dopaminergic neurons in the substantia nigra pars compacta, presumably mediated by apoptosis. The homeobox transcription factors engrailed 1 and engrailed 2 are expressed by this neuronal population from early in development to adulthood. Despite a large mid-hindbrain deletion in double mutants null for both genes, mesencephalic dopaminergic...

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PMID: 15175251
DOI: 10.1242/dev.01128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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