Article

SIRT1 limits neuronal fate following DNA damage

2025-05-19

Abstract excerpt

DNA damage is a major risk factor for the decline of neuronal functions with age and neurodegenerative diseases. The connection between DNA damage and neurodegeneration is extensively investigated, however, the mechanisms limiting the propagation of damaged DNA from highly replicative neural stem/progenitor cells (NSPCs) to post-mitotic neurons remains largely unknown. Here, we describe that enzymatic activity of...

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Literature Corpus work: 8f710f76-b2c7-5c68-9876-318e7e4c5c3f
DOI: 10.1101/2025.05.19.654885

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