Article

Nigral Transcriptomic Profiles in Engrailed-1 Hemizygous Mouse Models of Parkinson’s Disease Reveal Upregulation of Oxidative Phosphorylation-Related Genes Associated with Resistance to Dopaminergic Neurodegeneration

2023-03-24

Abstract excerpt

1. Engrailed 1 (EN1) is a conserved transcription factor essential for programming, survival, and maintenance of midbrain dopaminergic neurons. En1 -hemizygosity ( En1 +/- ) leads to a spontaneous Parkinson’s disease-like (PD-like) progressive nigrostriatal degeneration as well as motor impairment and depressive-like behavior in SwissOF1 (OF1 -En1 +/- ) mice. This phenotype is absent in C57Bl/6j (C57 -En1 +/-...

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Literature Corpus work: 959c3aa8-8e48-5d14-970c-d51d69c19f9f
DOI: 10.1101/2023.03.22.533733

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