Article

LINE-1 activation in the cerebellum drives ataxia

2021-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Previous studies have revealed that dysregulation of long interspersed nuclear element 1 (LINE-1), a dominant class of transposable elements in the human genome, correlates with neurodegeneration 1–3 . Yet whether LINE-1 dysregulation is causal to disease pathogenesis has not been proven directly. Here, we demonstrate that expression of evolutionarily younger LINE-1 families is elevated in the...

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Literature Corpus work: d496fb5a-ed55-5404-a777-34a404b531e8
DOI: 10.1101/2021.12.03.471151

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