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Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons

12 Jul 2016

Abstract excerpt

The LIM-homeodomain transcription factors Lmx1a and Lmx1b play critical roles during the development of midbrain dopaminergic progenitors, but their functions in the adult brain remain poorly understood. We show here that sustained expression of Lmx1a and Lmx1b is required for the survival of adult midbrain dopaminergic neurons. Strikingly, inactivation of Lmx1a and Lmx1b recreates cellular features observed in...

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PMID: 27407143
DOI: 10.1073/pnas.1520387113

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