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Article

Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.

Neural development - 16 Mar 2009

Alavian Kambiz N, Sgadò Paola, Alberi Lavinia, Subramaniam Srinivasa, Simon Horst H

Abstract excerpt

BACKGROUND: The homeodomain transcription factors Engrailed-1 and Engrailed-2 are required for the survival of mesencephalic dopaminergic (mesDA) neurons in a cell-autonomous and gene-dose-dependent manner. Homozygote mutant mice, deficient of both genes (En1-/-;En2-/-), die at birth and exhibit a loss of all mesDA neurons by mid-gestation. In heterozygote animals (En1+/-;En2-/-), which are viable and fertile,...

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Identifiers

PMID: 19291307
DOI: 10.1186/1749-8104-4-11
PMCID: PMC2667502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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