Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis.

Disease models & mechanisms - 26 Feb 2018

Sorrells Shelly, Nik Sara, Casey Mattie J, Cameron Rosannah C, Truong Harold, Toruno Cristhian, Gulfo Michelle, Lowe Albert, Jette Cicely, Stewart Rodney A, Bowman Teresa V

Abstract excerpt

RNA splicing factors are essential for the viability of all eukaryotic cells; however, in metazoans some cell types are exquisitely sensitive to disruption of splicing factors. Neuronal cells represent one such cell type, and defects in RNA splicing factors can lead to neurodegenerative diseases. The basis for this tissue selectivity is not well understood owing to difficulties in analyzing the consequences of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoprotection
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Essential

Share to Radiation, Ionizing

Share to Radiation Tolerance

Share to RNA Splicing

Share to Spliceosomes

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29419415
DOI: 10.1242/dmm.031583
PMCID: PMC5894942

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spliceosomal components protect embryonic neurons from R-loop-mediated DNA damage and apoptosis.PMID 29419415Read ↗

R-loops in neurodegenerationSemantic proximity Read ↗

DHX9 helicase promotes R-loop formation in cells with impaired RNA splicingSemantic proximity Read ↗

DNA Repair Deficiency and NeurodegenerationSemantic proximity Read ↗

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development.Semantic proximity Read ↗

Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during agingSemantic proximity Read ↗

Out of balance: R-loops in human disease.Semantic proximity Read ↗

DNA strand break repair and neurodegeneration.Semantic proximity Read ↗

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagySemantic proximity Read ↗

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficitsSemantic proximity Read ↗

My road to alternative splicing control: from simple paths to loops and interconnections.Semantic proximity Read ↗

Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition.Semantic proximity Read ↗

The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.