Endonuclease VIII ‐like 1 deficiency potentiates nigrostriatal dopaminergic neuron degeneration in a male mouse model of Parkinson's disease

Abstract excerpt

Abstract Parkinson's disease (PD) is a common movement disorder caused by a characteristic loss of dopaminergic neurons in the substantia nigra and degeneration of dopamine terminals in the dorsal striatum. Previous studies have suggested that oxidative stress‐induced DNA damage may be involved in PD pathogenesis, as steady‐state levels of several types of oxidized nucleobases were shown to be elevated in PD...

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