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Article

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.

PLoS biology - 1 Nov 2004

Martinat Cecile, Shendelman Shoshana, Jonason Alan, Leete Thomas, Beal M Flint, Yang Lichuan, Floss Thomas, Abeliovich Asa

Abstract excerpt

The hallmark of Parkinson's disease (PD) is the selective loss of dopamine neurons in the ventral midbrain. Although the cause of neurodegeneration in PD is unknown, a Mendelian inheritance pattern is observed in rare cases, indicating a genetic factor. Furthermore, pathological analyses of PD substantia nigra have correlated cellular oxidative stress and altered proteasomal function with PD. Homozygous mutations...

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Identifiers

PMID: 15502868
DOI: 10.1371/journal.pbio.0020327
PMCID: PMC521171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism.PMID 15502868Read ↗

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.Semantic proximity Read ↗

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.Semantic proximity Read ↗

PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic NeuronsSemantic proximity Read ↗

Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1Semantic proximity Read ↗

Lessons from Drosophila models of DJ-1 deficiency.Semantic proximity Read ↗

Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.Semantic proximity Read ↗

DJ-1 has a role in antioxidative stress to prevent cell death.Semantic proximity Read ↗

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.Semantic proximity Read ↗

Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.Semantic proximity Read ↗

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damageSemantic proximity Read ↗

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neuronsSemantic proximity Read ↗

Inactivation of <i>Drosophila</i> DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signalingSemantic proximity Read ↗

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