Article

Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer

2026-05-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Transcriptional regulation is shaped by both genomic variants and the environment. Yet, how the regulatory effects of genomic variants are reconfigured by dynamic epigenomic changes during tumorigenesis remains incompletely understood. <h4>Methods</h4> We investigated methylation context-dependent links between genotype and gene expression in colorectal cancer (CRC) using p...

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Literature Corpus work: 37a67d09-4dd0-51e1-805f-756343f777a4
DOI: 10.64898/2026.05.27.728350

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